Effect of Garcinia Kola upon alcohol induced Hyperuricemia
Introduction: Garcinia kola has been hypothesized to enhance alcohol clearance or oxidation, however, its influence on alcohol-induced hyperuricemia is yet to be documented. Therefore, this study investigated the hyperuricemia effect of Garcinia kola on ethanol-induction. Materials and Methods: 20 male adult albino rabbits were adopted and categorized into five experimental groups of A- E. Rabbits in group “A” (control) was treated with normal diet and distilled water only, while group “B” was given Garcinia kola plus fed in a ratio of 1:4 and later orally received 0.125g (20%) ethanol /kg body weight (small dose). Group “C” and D animals received Garcinia kola plus fed in a ratio of 1:4 in addition; administered 0.550g and 1.100g (20%) ethanol per kg body weight (as moderate and large doses) respectively. Group “E” was given 1.100g ethanol/ kg body weight only. The different regimens adopted for all animals were conducted for 12 weeks and the ethanol delivered as a single daily dose. Institution Ethical approval was obtained with ref No: DELSU/CHS/MBC/70/144. Result: Changes in serum urate induced by the different treatment procedures and statistical analysis demonstrated that the toxicant caused 43.4% increase from the basal value (0 Week) and 33.7% when compared with the control, meanwhile in the presence of G. kola, groups B, C, and D generated a change of 6.9%, 8.3%, and 11.7% respectively when compared the normal group. At the 12th week, the % change from basal values for G. kola treated groups are 15.7, 17.3, 18.1 with increasing ethanol dosage. Conclusion: From this study, G. kola demonstrated potential of attenuating ethanol-induced hyperuricemia, albeit human studies are required to corroborate animal model for predicting potential human consequences.