Attenuation of Female Reproductive Hormones in Piroxicam Administered Wistar Rats
One of the most commonly used drugs in today’s world is the Nonsteroidal Anti- inflammatory Drugs (NSAIDs). These drugs are renowned for their role in anti- inflammations, as well as in reducing muscular and joint pains. Though several studies have acknowledged the role of Piroxicam (an NSAID) in the treatment and/or management of rheumatoid arthritis, osteoarthritis, acute gout, ankylosing spondylitis, acute musculoskeletal disorders and dysmenorrhoea, very little or riff information details its implications in the endocrine and reproductive systems. To this point, this study was geared towards investigating in wistar rats, the attenuated effect(s) of Piroxicam administration on female reproductive hormonal levels. Twenty (24) adult female wistar rats (between 160-220g) were divided into four (4) groups of six rats each (n=6). While group 1 served as control (fed with normal diet), group 2 animals were administered with Piroxicam (0.1mg/kg), with group 3 given 0.2mg/kg of Piroxicam. Group 4 rats were co-administered with 0.2mg/kg of Piroxicam and Vitamin E. following period of administration of test substance, rats were sacrificed, blood samples collected and centrifuged to obtain serum for biochemical analysis. Hormone levels were analysed using Enzyme Linked Immunosorbent assay (ELISA). Analysis of Variance (ANOVA) shows a significant decrease (p < .05) in hormone levels of groups 2 and 3 rats upon comparison with those in control group. Antioxidant Vitamin E helped in antagonizing the effects of Piroxicam, showing less decrease in hormone levels. By decreasing oestrogen, progesterone and gonadotropins levels, NSAIDs can therefore be said to pose negative effects on female fertility.
Keywords: NSAIDs, Piroxicam, Hormones