Attenuation of Female Reproductive Hormones in Piroxicam Administered Wistar Rats

Nwangwa E. K; Anachuna K. K; Chijioku-Agbonifo E; Odigie O. M

1. Makar, R.S. and Toth, T.L. (2002): The evaluation of infertility. Am J ClinPathol; 117 (1): 95–103.
2. Gurunath, Z., Richard, A. and S. Bhattacharya, (2011). Defining infertility- a systematic review of prevalence studies. Human Reproduction.; 17 (5): 575-588.
3. Himmel, W., Ittner, E., Kochen, M.M., Michelmann, H.W., Hinney, B., Reuter, M., Kallerhoff, M. and Ringert, R.H. (1997). "Voluntary Childlessness and being
4.
5.
Childfree". British Journal of General Practice. 47(415): 111–8.
Gerais, A.S. and Rushwan, H. (1992) Infertility in Africa. 12:25-46.
Wartofsky, L., Van Nostrand, D. and Burman, K.D. (2006). "Overt and 'subclinical' hypothyroidism in women".Obstetrical&gynecological. 61 (8): 535–42.
Buer, J.K.(2014). Origins and impact of the term “NSAID'". Inflammopharmacology. 22(5):263–7.
Karim, A., Noveck, R., McMahon, F. G., Smith, M., Crosby, S., Adams, M. and Wilton, J. (1997), Oxaprozin and Piroxicam, NonsteroidalAntiinflammatory Drugs with Long Half-Lives: Effect of Protein-Binding Differences on Steady-State Pharmacokinetics. The Journal of Clinical Pharmacology, 37: 267–278.
8. Kaufman, D.W., Kelly, J.P., Rosenberg, L., Anderson, T.E. and Mitchell, A.A. (2002). Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey. JAMA. 287:337–344
9. Schisterman, E., Silver, R., Lesher, L., Faraggi, D., Wactawski-Wende, J., Townsend, J., Lynch, A., Perkins, N., Mumford, S. and Galai, N. (2014). Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial. Lancet. 384:29–36.
10. Al-Rubayi, F.K. (2004). Pharmacological effects of low-doses of aspirin on ovulatory state and corpus luteum functions in mature female mice. A thesis submitted to the college of medicine, University of Baghdad.
11. Ushikubi, F., Sugimoto, Y., Ichikawa, A. and Narumiya, S. (2000). Role of prostanoids revealed from studies using mice lacking specific postanoidreceptors.J.P.J.Pharmacol.83(4):27 9-85.
12. Ojeda, S.R., Negro, V.and McCann, S.M.(1982). Evidence of involvement of alpha adrenergic receptors in nor- epinephrinic-induced prostaglandin E2 AND LH releasing hormone release from the
median 412
eminence.Endocrinology.110:409-
13. Norman, R.J. consequences
(2001).
of COX-2
inhibition.358:1287–8
14. Chandra, J. and Antipyretics in Pediatr.69(1):69-74
Bhatnagar, K. children.(2002). Indian. J. Reproductive
15. Gayta ́n, F., Tarradas, E.,
Morales, C. andSa ́nchez-Criado, J.E.
Bellido, C., (2002). A Prostaglandin E1 inhibits abnormal follicle rupture and restores ovulation in indomethacin-treated rats. Biology of Reproduction. 67:1140–1147.
16. Gaytan, M., Morales, C., Bellido, C., Sanchez-Criado, J.E. and Gaytan, F. (2006) Non-steroidal anti-inflammatory drugs (NSAIDs) and ovulation: lessons from morphology. Histology and Histopathology.21:541–556
17.Uhler, M.L., Hsu, J.W., Fisher, S.G. and Zinaman, M.J. (2001). The effect of nonsteroidal anti-inflammatory drugs on ovulation: a prospective, randomized clinical trial. FertilSteril. 76:957–961.
18. Usoh, I.F., Akpan, E.J. and Etim,E.O. (2005). Antioxidants actions of dried flower extracts of Hibiscus sabdarifa L. on sodium arsenite induced oxidative stress in rats. Pak. J. Nutr. 4(3):135–41.
19. Galati, G., Tafazoli, S. and Sabzevari, O. (2002). Idiosyncratic NSAID drug induced oxidative stress. ChemBiol Interact. 142:25– 41.
20. Zielinski, H. and Kozlowska, H., Antioxidant activity and phenolics in selected cereal grains, their different morphological fraction. (2000).J Agric Food Chem. 48:2008–16.

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Affiliations

Nwangwa E. K
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.

Anachuna K. K
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.

Chijioku-Agbonifo E
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta

Odigie O. M
Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Delta State University, Abraka, Delta State, Nigeria.

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E. K, N., K. K, A., E, C.-A., & O. M, O. (2018). Attenuation of Female Reproductive Hormones in Piroxicam Administered Wistar Rats. International Journal of Forensic Medical Investigation, 4(1), 72-83. Retrieved from https://ijfmi.org/index.php/JSD/article/view/77

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Attenuation of Female Reproductive Hormones in Piroxicam Administered Wistar Rats

Nwangwa E. K ,
Anachuna K. K ,
Chijioku-Agbonifo E ,
Odigie O. M

Vol 4 No 1 (2018): Volume 4 Number 1

Submitted: Jul 4, 2019

Published: Apr 2, 2018

Abstract

One of the most commonly used drugs in today’s world is the Nonsteroidal Anti- inflammatory Drugs (NSAIDs). These drugs are renowned for their role in anti- inflammations, as well as in reducing muscular and joint pains. Though several studies have acknowledged the role of Piroxicam (an NSAID) in the treatment and/or management of rheumatoid arthritis, osteoarthritis, acute gout, ankylosing spondylitis, acute musculoskeletal disorders and dysmenorrhoea, very little or riff information details its implications in the endocrine and reproductive systems. To this point, this study was geared towards investigating in wistar rats, the attenuated effect(s) of Piroxicam administration on female reproductive hormonal levels. Twenty (24) adult female wistar rats (between 160-220g) were divided into four (4) groups of six rats each (n=6). While group 1 served as control (fed with normal diet), group 2 animals were administered with Piroxicam (0.1mg/kg), with group 3 given 0.2mg/kg of Piroxicam. Group 4 rats were co-administered with 0.2mg/kg of Piroxicam and Vitamin E. following period of administration of test substance, rats were sacrificed, blood samples collected and centrifuged to obtain serum for biochemical analysis. Hormone levels were analysed using Enzyme Linked Immunosorbent assay (ELISA). Analysis of Variance (ANOVA) shows a significant decrease (p < .05) in hormone levels of groups 2 and 3 rats upon comparison with those in control group. Antioxidant Vitamin E helped in antagonizing the effects of Piroxicam, showing less decrease in hormone levels. By decreasing oestrogen, progesterone and gonadotropins levels, NSAIDs can therefore be said to pose negative effects on female fertility.

Keywords: NSAIDs, Piroxicam, Hormones

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Attenuation of Female Reproductive Hormones in Piroxicam Administered Wistar Rats

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