Abstract

Background:


3,4-Methylenedioxymethamphetamine (MDMA), a common recreational drug, is known for neurotoxicity, but its effects on female reproductive organs are less understood. Oxidative stress may mediate its toxicity in non-neural tissues.


Materials and Methods:


Thirty adult female Wistar rats were divided into three groups: control, MDMA 80 mg/kg, and MDMA 160 mg/kg. MDMA was administered orally for 28 days daily. Post-treatment, ovarian and uterine tissues were analyzed for oxidative stress markers (SOD, CAT, GPx, MDA), and remaining rats were mated to assess fertility. Data were analyzed using one-way ANOVA and LSD post hoc tests (p ≤ 0.05).


Results:


MDMA significantly disrupted oxidative balance in reproductive tissues. Group C showed the greatest reduction in antioxidant enzymes (SOD, CAT, GPx), while lipid peroxidation (MDA) peaked in Group B. Uterine tissues showed a similar oxidative pattern.


Conclusion:


MDMA induces dose-dependent oxidative stress in the ovaries and uterus, posing potential risks to female reproductive health and fertility.