Abstract

With a growing body of research focusing on its biochemical pathways, particularly in the context of neurodegenerative diseases, this review aims to synthesize current findings within the Nigerian research landscape. Understanding the role of naringin in neuroprotection is crucial, given the increasing prevalence of neurological disorders in the region. This review employed a comprehensive literature search, analyzing studies published in Nigerian journals, as well as international research relevant to naringin and its neuroprotective mechanisms. Key databases were searched for articles examining naringin's effects on oxidative stress, inflammation, and apoptosis in neuronal cells. The findings indicate that naringin exhibits significant neuroprotective effects through various mechanisms, including its antioxidant activity, anti- inflammatory properties, and ability to inhibit neuronal apoptosis. Studies reviewed show that naringin can enhance cognitive functions and may offer therapeutic benefits in conditions such as Alzheimer’s disease and other neurodegenerative disorders prevalent in Nigeria.The neuroprotective mechanisms of naringin suggest its potential as a therapeutic agent against neurological disorders. Despite the promising results, the review highlights a gap in large-scale clinical trials within Nigeria. It emphasizes the need for further research to validate these findings and explore the translational potential of naringin in clinical settings. Naringin presents a compelling case for further investigation into its neuroprotective properties, particularly within the Nigerian context. The existing studies provide a foundation for future research aimed at harnessing naringin's therapeutic potential, ultimately contributing to improved management strategies for neurodegenerative diseases