Haematological parameters and antioxidants of Wistar rats fed with juice extract of Citrillus Lantus
The study investigated the effect of Citrullus lanatus juice extract on haematological parameters and antioxidant of male Wistar Albino Rat. Thirty (30) male Wistar rats weighing 150-200g were randomized into four groups and were treated orally within Citrullus lanatus extract for twenty one days. Group 1 (control) received normal fluid and water only, Group two (low dose) received 2.5ml/kg, Group three (medium dose) received 5ml/kg and Group four (high dose) received 10ml/kg of the extract for a period of 21days. At the end of the experiment the rats were sacrificed and the blood sample was statistically analyzed using ANOVA, followed by Duncan multiple range test. (P<0.05) were considered statistically significant. The finding showed there was a significant effect on the antioxidant. In malondialdehyde, there was a significant increase in the groups that were administered with extract at low dose (2.58±0.10) when compared with the control group (2.36±0.12), medium dose (2.42±0.06) and high dose (1.98±0.23). There was significant difference when compared control group with high dose. In catalase, there is significant difference between the treated groups at low dose (2.95±0.48), medium dose (3.13±0.37) and high dose (2.03±0.20). There is significance increase in Superoxide when in medium dose was compared with control group. Also there is significant differences (p<0.05) in the groups administered with C.lanatus extract at low dose (1.59±0.11), medium dose (1.36±0.11) and high dose (1.55±0.04). Finally there was no significant difference in PCV at low dose (46.20±2.48), medium dose (45.20±0.80), and high dose (44.00±1.52) when compared with the control (45.20±1.28). There was significant increase in basophil when medium dose (0.60±0.24) when compared with low dose (0.00±0.00) and high dose (0.00±0.00). This result suggest that the administration of Citrullus lanatus has no effect on PCV, Haemoglobin but rather decreased body weight.